The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and a bit soluble in Alcoholic beverages. The molecular body weight is 406.37. Its molecular formula is C18H21NO3•H3PO4 • ½ H2O, and it's the following chemical composition.
The next laboratory exams could be impacted in individuals that are receiving therapy with promethazine hydrochloride.
Antiemetics are usually not advised for treatment method of uncomplicated vomiting in pediatric individuals, and their use needs to be restricted to extended vomiting of acknowledged etiology. The extrapyramidal signs which could take place secondary to Promethazine HCl Oral Alternative administration may very well be bewildered Along with the CNS signs of undiagnosed Main illness, e.g., encephalopathy or Reye's syndrome. Using Promethazine HCl Oral Solution needs to be prevented in pediatric patients whose signs and indications may well propose Reye's syndrome or other hepatic illnesses.
Patients needs to be encouraged to measure Promethazine HCl Oral Alternative by having an correct measuring system. A household teaspoon will not be an correct measuring machine and could lead on to overdosage, specially when a 50 % a teaspoon is measured.
Promethazine HCl Oral Resolution and specific other medicines can interact with each other. Explain to your Health care professional about many of the medicines you take which includes prescription and non-prescription medicines, natural vitamins, and herbal health supplements.
Narcotic analgesics may perhaps cause nausea and vomiting by stimulating the chemoreceptor set off zone (CTZ); even so, In addition they depress the vomiting Centre, so that subsequent doses are unlikely to supply vomiting. Nausea is nominal immediately after standard oral doses of codeine.
Promethazine really should not be Employed in pediatric sufferers fewer than two several years of age due to the prospective for lethal respiratory depression.
Excessively massive dosages of antihistamines, which includes Promethazine HCl Oral Solution, in pediatric individuals may perhaps bring about unexpected Loss of life (see OVERDOSAGE). Hallucinations and convulsions have happened with therapeutic doses and overdoses of Promethazine in pediatric clients. In pediatric patients who're acutely unwell affiliated with dehydration, There is certainly an increased susceptibility to dystonias with using Promethazine HCl.
Caution really should be exercised when administering Promethazine to pediatric patients 2 a long time of age and older. It is suggested that the lowest powerful dose of Promethazine be Employed in pediatric clients 2 decades of age and more mature and concomitant administration of other medicines with respiratory depressant effects be prevented.
Everyday living-threatening respiratory despair and Loss of life have happened in youngsters who received codeine. Most of the claimed scenarios transpired following tonsillectomy and/or adenoidectomy, and many of the youngsters had proof of remaining an ultra-speedy metabolizer of codeine as a result of a CYP2D6 polymorphism [see Warnings and Precautions (five.
Steer clear of the usage of Promethazine HCl and Codeine more info Phosphate Oral Resolution in adolescents twelve to eighteen several years of age who have other possibility factors which could maximize their sensitivity towards the respiratory depressant consequences of codeine unless the advantages outweigh the threats.
Neuroleptic malignant syndrome (NMS) which may lead to Demise. Inform you healthcare provider right away When you have any of the following symptoms of NMS:
Increased pressure inside your head (elevated intracranial stress). Stay away from the usage of Promethazine Hydrochloride and Codeine Phosphate Oral Answer For those who have a head injuries or are already advised that you've modifications inside the tissue of your Mind (brain lesions) or improved pressure in your head.
Antihistamines are contraindicated for use in the cure of reduced respiratory tract signs and symptoms together with asthma.